Non-Canonical Modular Domain Interactions Dictate PKCα Function
نویسندگان
چکیده
منابع مشابه
Sampling Rate Conversion in the Discrete Linear Canonical Transform Domain
Sampling rate conversion (SRC) is one of important issues in modern sampling theory. It can be realized by up-sampling, filtering, and down-sampling operations, which need large complexity. Although some efficient algorithms have been presented to do the sampling rate conversion, they all need to compute the N-point original signal to obtain the up-sampling or the down-sampling signal in the tim...
متن کاملPolar residues and their positional context dictate the transmembrane domain interactions of influenza A neuraminidases.
Interactions that facilitate transmembrane domain (TMD) dimerization have been identified mainly using synthetic TMDs. Here, we investigated how inherent properties within natural TMDs modulate their interaction strength by exploiting the sequence variation in the nine neuraminidase subtypes (N1-N9) and the prior knowledge that a N1 TMD oligomerizes. Initially, consensus TMDs were created from ...
متن کاملA Least Angle Regression Model for the Prediction of Canonical and Non-Canonical miRNA-mRNA Interactions
microRNAs (miRNAs) are short non-coding RNAs with regulatory functions in various biological processes including cell differentiation, development and oncogenic transformation. They can bind to mRNA transcripts of protein-coding genes and repress their translation or lead to mRNA degradation. Conversely, the transcription of miRNAs is regulated by proteins including transcription factors, co-fa...
متن کاملModular Ontology Design Using Canonical Building Blocks in the Biochemistry Domain
The field of BioInformatics has become a major venue for the development and application of computational ontologies. Ranging from controlled vocabularies to annotation of experimental data to reasoning tasks, BioOntologies are advancing to form a comprehensive knowledge foundation in this field. With the Glycomics Ontology (GlycO), we are aiming at providing both a sufficiently large knowledge...
متن کاملSoft Interactions with Model Crowders and Non-canonical Interactions with Cellular Proteins Stabilize RNA Folding.
Living cells contain diverse biopolymers, creating a heterogeneous crowding environment, the impact of which on RNA folding is poorly understood. Here, we have used single-molecule fluorescence resonance energy transfer to monitor tertiary structure formation of the hairpin ribozyme as a model to probe the effects of polyethylene glycol and yeast cell extract as crowding agents. As expected, po...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.2643